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We are making an. We are making an. 1-10 of 82 3. cof mips 720pi fax efax efax line connection cocokc/shark/shark2. 3-5 of 83Thioredoxin mediates senescence-associated phenotypes in human diploid fibroblasts.
Cellular senescence is a differentiation-like process that can be triggered by a variety of stresses and environmental insults. In the context of oxidative stress, the cellular redox regulator thioredoxin (Trx) has been implicated as playing an important role in preventing the deleterious consequences of oxidative damage to mitochondria. In this work, we have examined the potential role of Trx in the senescence process. Our results show that the overexpression of Trx in human diploid fibroblasts (HDFs) using a recombinant adenovirus induces phenotypic changes that resemble those observed in senescent cells such as cell-cycle arrest, morphological alterations, and acquisition of a senescence-associated secretory phenotype (SASP). In addition, the oxidative stress-induced depletion of Trx partially overcomes cell-cycle arrest. Consistent with the notion that oxidative stress is at least partially responsible for the induction of the senescent phenotype, we show that overexpression of Nrf2, a master regulator of the antioxidant response pathway that is activated by oxidative stress, markedly suppresses Trx expression and partially reverses the activation of the senescence-associated pathway. Our data suggest a new role for Trx in the induction of senescence and, in general, highlight a role for Trx in the protection against oxidative stress and the induction of cellular senescence.1. Technical Field
The present invention relates to a mobile terminal and a keypad, and more particularly to a mobile terminal in which a keypad and a display are integrated and a keypad.
2. Related Art
As shown in FIG. 1, a mobile terminal of the related art includes an upper surface cover 2 that faces a display 1, and has a structure in which a keypad 3 is integrally integrated with a display 1 on an upper surface thereof.
In the conventional mobile terminal in which the keypad 3 is integr